KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
16.06
Human Site:
Y397
Identified Species:
27.18
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
Y397
E
N
Y
R
I
M
S
Y
F
K
E
A
E
L
K
Chimpanzee
Pan troglodytes
XP_521839
646
71607
Y397
E
N
Y
R
I
M
S
Y
F
K
E
A
E
L
K
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
M352
N
I
F
I
C
H
K
M
Q
S
D
S
P
G
V
Dog
Lupus familis
XP_534051
887
95991
Y638
E
N
Y
R
S
M
S
Y
F
T
E
A
E
L
K
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
Y396
E
N
Y
R
V
M
S
Y
L
T
E
V
E
L
K
Rat
Rattus norvegicus
Q63802
646
71478
F397
N
Y
R
V
M
S
Y
F
T
E
A
E
L
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
S356
V
H
M
D
I
K
P
S
N
I
F
I
S
R
T
Chicken
Gallus gallus
NP_001026352
641
70947
Y393
E
N
Y
R
N
M
R
Y
F
T
E
P
E
L
K
Frog
Xenopus laevis
P47817
555
61670
I338
S
G
L
V
H
M
D
I
K
P
S
N
I
F
I
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
H384
S
R
G
L
K
Y
I
H
S
T
A
L
V
H
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
Q385
L
V
E
V
Q
P
Q
Q
T
K
D
D
D
G
M
Honey Bee
Apis mellifera
XP_624069
589
66032
R373
I
F
I
S
K
E
K
R
L
L
A
V
N
Y
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
A392
K
Q
V
L
V
Q
I
A
Q
G
L
K
Y
I
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
L284
V
K
H
S
T
R
K
L
Y
L
D
S
E
R
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
0
86.6
N.A.
73.3
0
N.A.
6.6
73.3
6.6
0
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
100
20
86.6
N.A.
80
20
N.A.
13.3
73.3
6.6
6.6
N.A.
20
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
0
22
22
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
0
22
8
8
0
15
% D
% Glu:
36
0
8
0
0
8
0
0
0
8
36
8
43
0
0
% E
% Phe:
0
8
8
0
0
0
0
8
29
0
8
0
0
8
0
% F
% Gly:
0
8
8
0
0
0
0
0
0
8
0
0
0
15
0
% G
% His:
0
8
8
0
8
8
0
8
0
0
0
0
0
8
8
% H
% Ile:
8
8
8
8
22
0
15
8
0
8
0
8
8
8
8
% I
% Lys:
8
8
0
0
15
8
22
0
8
22
0
8
0
8
36
% K
% Leu:
8
0
8
15
0
0
0
8
15
15
8
8
8
36
0
% L
% Met:
0
0
8
0
8
43
0
8
0
0
0
0
0
0
15
% M
% Asn:
15
36
0
0
8
0
0
0
8
0
0
8
8
0
0
% N
% Pro:
0
0
0
0
0
8
8
0
0
8
0
8
8
0
0
% P
% Gln:
0
8
0
0
8
8
8
8
15
0
0
0
0
0
0
% Q
% Arg:
0
8
8
36
0
8
8
8
0
0
0
0
0
15
8
% R
% Ser:
15
0
0
15
8
8
29
8
8
8
8
15
8
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
15
29
0
0
0
0
8
% T
% Val:
15
8
8
22
15
0
0
0
0
0
0
15
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
36
0
0
8
8
36
8
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _